INDEX

1 - General
2 - Brief description
3 - Installation
4 - Using GNUPLOT with GEPASI

======================================================================
1 - General

This is GEPASI 2.0, a general purpose simulator of metabolic pathways.
It is a directed towards research and education; it is meant to be a
very useful tool for modelling biochemical pathways, chemical 
reactions,etc. GEPASI is free software covered by the GNU general
public license, version 1.

This version of GEPASI runs under MS-Windows 3.0 and 3.1 in 386
enhanced mode, on 80386SX and above microprocessors. A maths
co-processor is not needed but should accelerate the simulations by at
least a factor of 10.

======================================================================
2 - Brief description

In order to simulate bichemical pathways, the user must first define
the reactions that are part of the pathway, all its parameters and 
initial concentrations of the metabolites (chemical species). GEPASI
then determines the dynamics and steady state (if there is one),
including the coefficients defined in Metabolic Control Analysis.
GEPASI can be used to study metabolic regulation, chemical and enzyme
kinetics including oscillatory (limit cycle) and chaotic reactions.

The file GEPASI.WRI contains a cut-down version of a paper to appear
in "Modern trends in Biothermokinetics", edited by J.-P. Mazat, S.
Schuster and M. Rigoulet and published by Plenum Press with a short
description of GEPASI. Another more detailed paper will shortly appear
in the journal "Computer Applications in the Biosciences".

For more detailed information see the help file (GEPASI.HLP). The 
subjects of metabolic simulation and metabolic control analysis are 
discussed in the mailing list btk-mca. To subscribe to this list send
a mail message to biosci@net.bio.net, post to the list to 
btk-mca@net.bio.net. Alternatively this list can be accessed via the
usenet newsgroup bionet.metabolic-reg

======================================================================
3 - Installation
    
   a) from a disk

      1 - put the installation disk in one drive (for example A:)
      2 - In MS-Windows' Program Manager select File-Run and enter
          A:SETUP.EXE

   b) from the zip file
     
      1 - unzip all files to a disk or directory
      2 - In MS-Windows' Program Manager select File-Run and enter
          A:SETUP.EXE (or the complete path where you've unzipped
          the files to)

======================================================================
4 - Using GNUPLOT with GEPASI

  To facilitate and speed up the production of plots of the data
generated by GEPASI, this can link to the popular freeware program
GNUPLOT. GNUPLOT has been included in GEPASI's distribution disks.
If you obtained GEPASI from an on-line archive or a CD-ROM then you
need to get GNUPLOT as well; look in directories named 'windows3' or
'plot'.

Instructions to make GEPASI aware of your copy of GNUPLOT (not needed
for the diskette version):

after installing GNUPLOT,

1 - In GEPASI - Simulation, select Plot...
2 - after pressing OK, find the file WGNUPLOT.EXE in the directory
    where you've installed GNUPLOT, select it and press ENTER.
3 - from now on use Plot... to make your plots!

GEPASI 2.0 (c) 1989,1992,1993 by Pedro Mendes.
prm@aber.ac.uk